Piperine is the alkaloid that gives black pepper, Piper nigrum (Piperaceae), and Piper longum L., also known as long pepper, their pungency.
Piperine Piperine is the most common dietary alkaloid found in the fruits and roots of the Piperaceae family's Piper nigrum L. (black pepper) and Piper longum L. (long pepper) species. Piperine is chemically 1-Piperoylpiperidine, and it is responsible for pepper's unique pungency and biting flavour. Antioxidant, anti-inflammatory, immunomodulatory, anti-asthmatic, anti-convulsant, anti-mutagenic, anti-mycobacterial, anti-amoebic, and anti-cancer properties have been discovered in it. Piperine has been shown to have chemopreventive properties against cancer cells of diverse origins by activating apoptotic signals and inhibiting cell cycle progression in numerous investigations. Piperine is also known for its effects on redox homeostasis, cancer stem cell (CSC) self-renewal, ER stress regulation, autophagy, cancer cell invasion, metastasis, and angiogenesis. It works by inhibiting P-gp and so reversing multidrug resistance in cancer cells. Piperine functions as a bioavailabi...