Immuno-Oncology Drugs Are Used For Boosting The Immune System And Destroying Cancerous Cells

 

Immuno-Oncology Drugs

Immuno-oncology uses medical treatments that harness the power of the immune system to fight cancer. These treatments can include cancer vaccines, checkpoint inhibitors, CAR-T cell therapy, dendritic cell therapy and other therapies that boost the body’s natural immune defenses.

Immuno-oncology is based on the understanding of how tumors are formed by coevolving groups of interactive cancer cells and immune cells. The tumor microenvironment contains many factors that prevent the immune response from eliminating cancer cells and promoting long-term control of cancer.

Immunotherapy uses the body’s immune system to fight cancer and has shown promising results in many patients. There are two major types of immunotherapy: T cell therapy and immune checkpoint blockade.

Immunotherapy uses the body’s natural immune system to improve on its ability to detect and fight cancerous cell growth. It is often used in combination with other treatments such as chemotherapy or radiation.

The immune system has receptor proteins that help distinguish healthy cells from invading cells. Sometimes these proteins become mutated to allow cancer cells to escape from the immune system. Some immunotherapy drugs block the proteins, thereby helping the immune system recognize cancer cells and attack them.

Other Immuno-Oncology Drugs change the normal cells around tumors so they are less likely to evade the immune system. Still others target specific features of cancer cells such as microsatellite instability-high (MSI-H), which indicates that a tumor may have a mutation that is responsive to immunotherapy.

Immunotherapy works by enhancing the immune system’s ability to recognize and destroy cancer cells. It uses vaccines, monoclonal antibodies and cellular therapies such as CAR T-cell therapy, to target specific parts of the immune system and improve the body’s natural response to fight cancer.

Astellas Pharma Inc., has submitted a New Drug Application for zolbetuximab to Japan's Ministry of Health, Labour and Welfare, in June 2023. If it is approved, then this will be first LDN18.2-targeted therapy in Japan.

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