Microcrystalline Cellulose Is The Most Commonly Used Excipient In The Global Pharmaceutical And Dietary Supplement Sector As It Adds Bulk And Texture To Medicines In Tablets And Capsules

 

Microcrystalline Cellulose

Microcrystalline Cellulose is a popular pharmaceutical excipient used in tablets and capsules to provide a bulking effect, enhance absorption, improve shelf life and optimize texture. It has a number of uses in food products, too.

Microcrystalline cellulose is a versatile, cost-effective, and safe excipient. Its low odor and ease of manufacturing makes it a good choice for all pharmaceutical and food applications. It is also an effective lubricant and bioadhesive, making it a good choice for bioadhesive drug delivery systems.

It is a strong dry binder, tablet disintegrant, absorbent, diluent and lubricant for direct compression as well as in liquid dosage forms. It has a wide range of applications in the food and pharmaceutical industries owing to its nutrient-rich, inert properties that deliver the active ingredient in a convenient, compact, and dosed form.

The most common use for Microcrystalline Cellulose is in direct compression, it can also be used as a thickening agent, binding agent and flow aid in tableting processes. Its high density makes it an excellent excipient for compressible tableting, while its thickening powers allow for more uniformly sized tablets with less waste.

MCC can be obtained by a variety of processing methods, including reactive extrusion, enzyme mediated, mechanical grinding, steam explosion and acid hydrolysis. It can also be spray-dried by varying the amount of reagents and conditions to control its particle size and moisture content.

It has a degree of polymerization (DP) typically less than 400 and can be used in any pharmaceutical or food application where it has the desired physicochemical properties such as crystallinity, moisture content, particle morphology, surface area, bulk density, etc.

Different manufactures produce a great deal of variability in Microcrystalline Cellulose properties, due to the kinds of pulp used as raw material and the application process parameters. The physicochemical properties of MCC depend on the synthesis and processing parameters such as the degree of polymerization, pH, temperature, and aqueous slurry flow.

This material is not soluble in water and only slightly soluble in most organic solvents. It is a good binder in both liquid and dry forms, has a very low odor and is easily absorbed by the body. Increasingly, Microcrystalline Cellulose is being incorporated into personal care products such as shampoos and lotions.

Pharmacel MCC 90, was launched by DFE Pharma in July 2021. This is a silicified microcrystalline cellulose that will help in broadening the company’s product portfolio.

 

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