Gene Synthesis; a Process of Creating Artificial Genes Using Synthetic Biology in a Lab

 

Gene Synthesis

Gene Synthesis, also known as artificial gene synthesis, is defined as the synthetic biology method used to engineer artificial genes in the laboratory. It is the process of synthesizing a gene in vitro without the need for initial template. It has been used for a wide variety of applications, including the development of safer DNA vaccines and to study the metabolic regulation of cancer cells. Gene synthesis can also be used for up-regulating or down-regulating genes of interest. It is also used to build operons and variant libraries.

Despite its many uses, it is still considered to be a relatively new technology. As compared to other forms of synthetic biology, it is relatively easy to use and offers a lot of possibilities for application. Gene Synthesis has many applications, including genetic engineering, agriculture, and targeted gene therapy. It has also been used to produce synthetic DNA libraries, which can be used to study complex pathways. Moreover, it is possible to use the technique to create plasmids, which can be used in computer-based gene synthesis protocols.

Gene Synthesis is often simpler, faster, and less expensive than using the alternative methods of molecular cloning and mutagenesis. This technology has emerged as a new application of genetic engineering, using oligonucleotides and different methods of assembling these to create stretches of double-stranded DNA usually cloned into a plasmid vector. The accurate synthesis of DNA is important in order to avoid mutations to DNA. It is reliable and cost-effective method for obtaining customized DNA constructs with 100% sequence accuracy.

With the increase in adoption of gene therapy and growing awareness about genetic engineering, the use of Gene Synthesis is also increasing. In April 2022, DNA Script reached agreements with several leading biotechnology distribution companies throughout the Asia-Pacific (APAC) region. These partnerships expand DNA Script’s worldwide footprint and provide sales and support for the SYNTAX DNA printing system in labs throughout the Asia-Pacific region.

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