Non-Invasive Biosensors Provide Accurate, Real-Time Information Pertinent To Metabolic Status of Samples under Investigation

 

A wide range of wearable electrochemical sensors and biosensors are been developed in Japan for real-time non-invasive monitoring of electrolytes and metabolites. Biomimicry, the study of biological and other information that can be used to develop or diagnose a disease, has been greatly advanced through the use of various techniques like non-invasive biosensors in clinical analysis. These non-invasive biosensors are capable of providing accurate, real-time information pertinent to the metabolic status of the samples under investigation. The applications of these types of biosensors in clinical analysis span the entire spectrum from determining the extent of an infection to detecting drug toxicity or the presence of a tumor.

One very efficient noninvasive biosensor used in clinical analysis is the method of detecting physiological activity using the reaction of the peripheral nervous system. Clinical research has shown that this method is capable of detecting muscle twitch, heartbeat, and water body temperature with extremely high accuracy. Another useful biosensor method is the method of detecting metabolic activity using radio frequency emissions from the skin, fat cells and blood. This method has also been used to monitor different parameters such as respiration and blood pressure.

Sweat analysis is another category of noninvasive, bioelectronic procedure. Samples of human/facial or epidermis secretions are analyzed. It probes into the proteins present in the secreted fluids of the body. After obtaining a sample from the skin, it compares the present composition of different species of bacteria in order to identify the presence of an imbalance. This technique is also useful in finding out the effect of diabetes, which results due to the lower activity of the sweat glands than the other parts of the skin. Besides all the categories of Non-Invasive Biosensors in clinical analysis, there are other devices that play a vital role in clinical practices. A patient's finger pulse test is another useful tool to diagnose certain diseases, such as diabetes.

Biosensors are electronic devices, which uses biological molecules such as enzymes, proteins, or antibodies for the detection and measurement of any substance or chemical. Non-invasive biomarkers are advanced diagnostic devices, which do not require incision or insertion of instruments/devices in the body. There is no contact with mucosa, or skin break, or internal body cavity for diagnosis. Non-invasive biosensor mainly uses tears, saliva, and sweat for the analysis and diagnosis of various diseases. There are few non-invasive biosensor devices available in market, however, a robust pipeline of novel non-biosensors is under development and under clinical trial. Key players in the market are focusing on research and development activities for development of novel non-invasive biosensors and to launch it in market.